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Supplementary Figures Acknowledgements We would like to thank the Scientific Technology Platforms (STPs) at The Francis Crick Institute, particularly High Throughput Screening for their collaboration to develop the arrayed CRISPR-Cas9 screen, and the Biological Research Facility for breeding and maintenance of mouse lines
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In other words, fewer calories in and more calories out
Smaller, more frequent meals typically work better during the initial adjustment period
Quick Note: Participants reported a daily food intake of 1500 to 1600 kcal, which is typical of a weight loss diet
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