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We synthesize how these metabolites recalibrate the tumor immune microenvironmentmodulating antigen presentation, T-cell effector fitness and exhaustion, regulatory T-cell activity, and myeloid polarizationand why the same metabolite can either potentiate immune surveillance or entrench immunosuppression depending on ligandreceptor pairing, dose and tissue niche
The samples were analysed by 520% PAGE and western blotting was performed using an anti-Met rabbit mAb (D1C2, Cell Signaling Technology)
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