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Adams TD, Davidson LE, Litwin SE, Kim J, Kolotkin RL, Nanjee MN, et al
The weight effect runs through several parallel mechanisms: it activates satiety centers in the hypothalamus so patients feel full sooner and stay full longer, it slows gastric emptying, it modulates reward pathways so calorie-dense foods feel less compelling, and it stabilizes post-meal glucose and insulin
The SURMOUNT-5 trial, published in The New England Journal of Medicine , directly compared tirzepatide to semaglutide and found tirzepatide produced 47% greater relative weight loss at 72 weeks, 20.2% of body weight versus 13.7%
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