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Given the reabsorption of renin by proximal tubule cells through megalin, and the broad expression of ACE within the kidney, allowing locally synthetized ANG II independent action, the interference of SGLT-2-i with intrarenal RAS could explain such results
Lancet 393 , 17451759 (2019)
Standalone cagrilintides peer-reviewed Phase 2 monotherapy result is about 10.8% at 26 weeks at 4.5 mg
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