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24 Table 3 Estimated Sensitivity and Specificity of Serum Laboratory Tests for Vitamin B12 Deficiency Pernicious anemia refers to one of the hematologic manifestations of chronic auto-immune gastritis, in which the immune system targets the parietal cells of the stomach or intrinsic factor itself, leading to decreased absorption of vitamin B 12
The NIH Office of Dietary Supplements and the American Academy of Family Physicians identify the following groups as most vulnerable: Adults over 50 Age-related decline in stomach acid production reduces the ability to release B12 from food proteins
The off-target MAO-A activity is concentration-dependent, so a bigger dose scales that too
What ICD-10 Codes Are Used for Pernicious Anemia
Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]
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