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According to 3 multicenter, randomized, double-blind, placebo-controlled obesity trials (BMI 30, or BMI 27 with at least 1 comorbidity of hypertension, dyslipidemia, or type 2 diabetes) conducted to evaluate the effect of CONTRAVE in conjunction with reduced caloric intake and increased physical activity, the average percentage of weight loss in patients at 56 weeks ranged from 3.7% to 8.1% with CONTRAVE, compared to 1.3% to 4.9% with placebo
ETCO , end-tidal carbon dioxide
Specifically in regard to nausea, it tended to be most pronounced in the first 4 weeks of therapy in all phase III LEAD trials, with symptoms generally dissipating over the remainder of the study period
It basically works by mimicking the GLP-1 hormone thats produced naturally by the body in the gut after an individual consumes food
Elevated cortisol from chronic stress promotes fat retention, particularly visceral fat
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