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GLP-1 medications complement but do not replace psoriasis-specific therapies

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doi: 10.1038/s41467-018-04719-2 45 SchimmerSMittermllerDWernerTGrsPEMeckelmannSWFinlayDKet al

As ATP hydrolysis has a free energy change of 50kJ/mol under physiological conditions we find that 228 kJ/mol suffices to produce a maximum of 228/504.5 ATPs

We identified P5 in a high-throughput autocrine-based screening of large combinatorial peptide libraries, and show that P5 promotes G-protein signalling comparable to GLP-1 and Exendin-4, but exhibited a significantly reduced -arrestin response