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The Non-Peptide GLP-1 Receptor Agonist WB4-24 Blocks Inflammatory Nociception by Stimulating -Endorphin Release From Spinal Microglia

Compared to usual care, participants who used GLP-1RAs had a lower risk of: substance use and psychotic disorders seizures neurocognitive disorders including Alzheimers disease and dementia infectious illnesses several respiratory conditions coagulation and cardiometabolic disorders, including deep vein thrombosis, pulmonary embolism, stroke, cardiac arrest, heart failure and myocardial infarction

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In addition, liraglutide could also induce the cell cycle arrest of vascular smooth muscle cells through the AMPK pathway, thereby delaying the formation of AS (130)