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Chronic hyperglycemia initiates a cascade of molecular eventsincluding the accumulation of advanced glycation end products (AGEs), activation of the polyol pathway, enhanced protein kinase C (PKC) signaling, and mitochondrial dysfunctionculminating in glomerular hyperfiltration, podocyte injury, and progressive glomerular and tubulointerstitial fibrosis
Wegovy, the higher-dose semaglutide specifically approved for weight management, has more limited availability
Weight loss is of course beneficial, but it doesnt fully explain the benefits seen in the heart, kidneys and liver
Eileen Barr, an obesity physician in East Setauket
Patients with a history of pancreatitis, for example, should be counseled about potential complications, medical studies show
