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However, direct comparisons require caution because: Trial lengths differed Dosing protocols differed Patient populations differed Long-term orforglipron data is still developing A 5% to 10% reduction in body weight can still produce clinically meaningful improvements in blood pressure, insulin sensitivity, mobility, and metabolic health

Injectable semaglutide (Ozempic) reduces HbA1c levels by 1.4%1.6% at week 30, again depending on the dosage strength

Of these, the most common side effects are usually the gastrointestinal ones , such as nausea, diarrhea, vomiting, and constipation

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