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Current guidelines recommend LDL cholesterol levels below 70 mg/dL in high-risk patients and below 55 mg/dL in very high-risk individuals [1, 20]
Delayed gastric emptying associated with GLP1/GIP receptor agonists may increase the risk of appendicitis due to changes in gastrointestinal motility
It also feeds into the GABA shunt, an alternative metabolic pathway that produces Gamma-aminobutyric acid (GABA), the brain's primary inhibitory neurotransmitter
In the short term, effects can include facial flushing and reduced appetite
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