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This discovery of filamentation evaded past crystallographic studies involving an engineered protein that removes a surface loop (residues 516525) 16,17,18 now revealed to be key to polymerisation, alongside the assumption that CBS is predominantly a tetrameric protein 12
Supporting this hypothesis, Horlick et al
Most other peptides used in clinical practice today are not on this list
One produces 8 percentage points more weight loss
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