Propionic acid also exerts protective effects on epithelial cells by inhibiting histone deacetylase (HDAC), thereby promoting the acetylation of histones such as H3K9ac and H3K14ac and subsequently increasing the expression of the tight junction protein ZO-1 and mucin MUC2 109
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Vascular adaptations linked to Klow are assessed using nitrate/nitrite quantification, VEGF protein and gene expression profiling, and endothelial tube formation assays