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At the same time, bile acid signaling pathways, including the farnesoid X receptor (FXR)FGF15 and TGR5glucagon-like peptide-1(GLP-1) axes, are disrupted, further promoting hepatic lipid accumulation and immune dysregulation
These multi-drug approaches address key limitations of single-agent treatments, optimizing fat loss while mitigating adverse effects like muscle atrophy or reduced efficacy
To achieve equivalent systemic levels, nasal spray users need to administer proportionally higher doses
10.14715/cmb/2023.69.9.15 7 AlshanwaniA
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