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Improvement and competition is expected over time, whether by creating more modifications to improve half-life , improving access to the brain, converting existing injectable drugs into oral forms, combining with other agonists or antagonists (Molecules that prevent receptors/molecules from functioning) such as DPP-4 inhibitors, which help extend the half-life of peptides such as GLP-1 and GIP
Colonic mRNA expression analysis in Glp1r / mice at baseline reveal significant reductions in trefoil factor ( Tff-1 and -2), transforming growth factor ( Tgf-b1 and Tgf-3 ), epidermal growth factor receptor ( Egfr ), keratinocyte growth factor ( Fgf7 ), hepatocyte growth factor ( Hgf ) (epithelial protection and repair), Il6, Il1b (innate immune response), Il12b (inflammation) (Yusta et al., 2015)
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Ferraretto A, Bottani M, Villa I, Giusto L, Signo M, Senesi P, et al
Limitations The presented findings indicate only associations and do not establish causal relationships
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