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doi: 10.1212/01.wnl.0000183063.99107.5c

Researchers have found that resveratrol and metformin provide protection to proximal tubular cells against high glucose-induced EMT and cellular senescence by activating the AMPK/mTOR signaling pathway (146)

Because U2OS cells do not express detectable procaspase-1, this result supports the idea that X(PC) can engage off-target apoptotic signaling when its intended substrate is absent

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For example, in soybean ( Glycine max ), exposure to iron deficiency followed by phosphate deficiency (-Fe -Pi) resulted in 2,975 DEGs in leaves and 10,612 DEGs in roots, of which 605 in leaves and 59 in roots were expressed exclusively under sequential stress