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For research design, adverse-event literature suggests endpoints and exclusion criteria

Net-beneficial preferred terms uric acid lowered -0.69/-0.92/-0.95 mg/dL (72.7% mediated by weight loss): Sattar Annals of the Rheumatic Diseases 2026

Retatrutide is an investigational triple-agonist (GLP-1, GIP, and glucagon) with a half-life of roughly 6 days (Coskun et al., Cell Metabolism, 2022)

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