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Early studies reported that pramlintide use in people with insulin-treated diabetes is associated with improved glycaemic control and may support weight loss by reducing food intake [77]
The assay involved the sequential addition of 2 mM malate, 5 mM glutamate, and 10 mM pyruvate (complex I leak respiration), 5 mM ADP (complex I oxidative phosphorylation), 10 mM succinate (complex I + II oxidative phosphorylation), 2.5 M oligomycin (complex I + II leak respiration), 0.5 M FCCP (maximal respiration), and 2.5 M antimycin A (non-mitochondrial respiration)
Conditions such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, and stroke have all been associated with elevated levels of oxidative stress
Depending on glycaemic response and tolerability, the dose may be further increased to 1 mg weekly after at least four weeks, with a maximum licensed dose of 2 mg weekly for diabetes management