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Its mechanism is competitive inhibition within the NNMT catalytic pocket, blocking the methyl transfer from SAM to nicotinamide
If you are using compounded medication, this is especially important because concentration varies by pharmacy
Additionally, the donation process requires donors to remain still for an extended period
The SURPASS trials showed A1c reductions of 1.24% to 2.58% depending on the dose and comparator
Improves insulin sensitivity, energy metabolism, and resistance to diet-related weight gain (proven in mice)
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