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Semaglutide independently reduces post-meal glucose spikes
The 0.25 mg dose is an initial titration dose designed to improve tolerability, not for glycaemic control, and elimination time is identical across all doses
These include: Enhanced glucose-dependent insulin secretion Suppressed glucagon secretion Slowed gastric emptying Increased satiety via central hypothalamic action This results in both glycaemic improvement and clinically meaningful weight loss
The anxiety makes clinical sense given the pace of change and the psychological significance of body image
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