Gallbladder-related issues: As with GLP-1 therapies, rapid weight loss may increase the risk of gallstones in some individuals
"These situations are very personal decisions that depend on a woman's medical condition, depend on the timing and the choice of medication that she's taking, and these should always, always, always be discussed with that woman's own prescribing clinician." Saunders also said tirzepatide, sold under the brand names Mounjaro and Zepbound, carries an FDA warning about use with oral birth control
Serious adverse events, including pancreatitis and gallbladder disease, are rare but documented
Temperature changes, chills, hair shedding, sulfur-tasting burps, and low mood appear in user reports but were measured thinly or not at all in trials
For autoimmune patients, these combination formulations may provide modest additional anti-inflammatory benefit beyond the GLP-1 alone