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Choline: critical role during fetal development and dietary requirements in adults
The drug increased the likelihood of achieving at least 5% body weight loss but was associated with higher rates of mild-to-moderate gastrointestinal side effects
Several other agents also showed significant effects
This body of evidence suggests that targeting the metabolism of the TME might have synergistic effects by alleviating multiple aspects of TME-induced vascular dysfunction and immune suppression
J Biomed Biotechnol 2011:609813 Lange S, Rocha-Ferreira E, Thei L, Mawjee P, Bennett K, Thompson PR, Subramanian V, Nicholas AP, Peebles D, Hristova M et al (2014) Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates
