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The target action date (PDUFA date) was initially set for late March but has shifted to approximately April 10 of this year
For example, in the treatment of cancer cachexia, some clinical trials are evaluating the effectiveness of combination therapy with other anti-cancer drugs, hoping to provide more effective treatment options for cancer patients
The biggest known risks are retatrutide-driven GI side effects (nausea 38-43%, diarrhea 33-35%) and dysesthesia - an unusual skin tingling or burning sensation at higher doses
Smaller divided doses may reduce these fluctuations
The analysis used Bayesian methods for network comparisons, with credible intervals confirming robustness, though limitations include indirect evidence and short-term follow-up (mostly 40-72 weeks)
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