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Its here that they upregulate the production of insulin and improve the health and activity of beta cells responsible for insulin creation when blood sugar increases.12 Tirzepatide also influences alpha cells in the pancreas responsible for creating glucagon, a kind of check against insulin that helps increase blood glucose as needed.13 Digestive tract Central nervous system GLP-1 RAs impact the central nervous system in numerous ways, but one of the most important is their ability to influence satiety the feeling of being full and satisfied.16 Satiety is a complex hormonal state, and when these medications affect it, you tend to feel fuller sooner and stay feeling full for longer, ultimately leading to a reduction in food intake

It is not the only GLP-1 option, and for some patients a different medicine fits better

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The treatment of obesity by control of appetite with diethylproprion (Tenuate)