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Using the common terminology criteria for adverse events (CTCAE - Version 5.0) to evaluate the severity of adverse events of anticancer therapies

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The type III ANOVA analysis via Satterthwaites degrees of freedom was performed using the R package lmerTest [47] to assess the significance of the main effects, whereas significant relationships were further explored via estimated marginal means analysis using the package emmeans V1.11.1 [48], thus, a Tukey-adjusted contrasts pair wise comparison was also carried out