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The doctors we talked to aren't surprised

Competitive Position Summary Orforglipron occupies a unique competitive position as the first oral non-peptide GLP-1 agonist approaching approval

Higher doses would accelerate fat loss but potentially amplify the side effects that could compromise training quality

The results of these trials have consistently demonstrated the cardiovascular benefits associated with GLP-1 receptor agonists including reductions in major adverse cardiovascular events

Compared to continued use, they found that stopping or interrupting GLP-1 treatment for as little as six months was linked to a significant increase in the risk of major cardiovascular events