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NHS therapeutic doses for deficiency are far higher than standard dietary reference values
Over time, free radicals can cause cell damage and contribute to the development of chronic disease
Clinical Findings of Target Organ Damage Target Organ Damage Hypertensive encephalopathy Intracranial hemorrhage Unstable angina Acute myocardial infarction Acute left ventricular failure with pulmonary edema Dissecting aortic aneurysm Eclampsia Clinical Findings Funduscopic: papilledema, hemorrhage, exudates Neurologic: somnolence, confusion, seizures, coma, visual deficits or blindness Cardiac: S4 gallop, ischemic changes on ECG, chest x-ray consistent with pulmonary edema, chest pain Renal: oliguria, progressive azotemia, hematuria, proteinuria Other: dyspnea Reprinted with permission from JNC-VII.
Patients and families benefit from education about newly FDA-approved therapies
Excessive ROS accumulation could induce neuronal apoptosis by disrupting mitochondrial membrane integrity [64], ultimately resulting in the loss of mitochondrial membrane potential [65]
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