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However, the recently concluded SAVOR-TIMI 53 trial conducted on patients with T2DM with either a history of established CVD or multiple CVD risk factors, has failed to demonstrate the superiority of saxagliptin over placebo in reducing a composite end point of cardiovascular death, nonfatal MI or nonfatal ischemic stroke when added to usual care [142, 143]

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But none had been isolated with incretin-like properties first described by La Barre which was considered to be ideal for the treatment of type 2 diabetes (Marks Samols

Acanthosis, hyperkeratosis, pseudoepitheliomatous hyperplasia, and, less frequently, parakeratosis are frequently observed, especially in the epithelioid and spindle cell nevi of junctional or compound type, more rarely in the epithelioid and spindle cell dermal variant