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The Assistive Devices Program in Ontario, for example, provides partial funding for eligible patients with confirmed moderate to severe sleep apnea
For a non-competing adult working with a physician willing to supervise off-label use, the risk-to-benefit profile may be acceptable given the volume of animal evidence, but anyone expecting human RCT-level proof is not yet there
In the case of utilizing experimental models similar to humans in preclinical research, the failure of clinical translation not only indicates that we need to find a preclinical model that is more suitable for humans but also motivates us to look for multi-target and multi-pathway neuroprotective drugs
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