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In this sense, some studies suggest that the cytokine storm that is present, especially in more severe COVID-19 patients, may activate the indoleamine 2,3-dioxygenase 1 (IDO-1) enzyme and, consequently, culminate in a drastic reduction of tryptophan, increases in toxic metabolites of the kynurenine pathway, and depression (Bouas et al
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For a brain suffering from an acute metabolic crisis, this delay is catastrophic
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