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Without selenium, glutathione cannot do its job effectively

Penicillamine, a copper chelator used in Wilson disease, requires dose adjustment in hepatic impairment precisely because liver function determines the rate at which mobilized copper can be processed and excreted [10]

Additionally, the overall high acetylation of H3 in heroin users correlates with the duration of use, resulting from altered functional balance of HAT and HDAC due to the drug 75,96,97,98,99,100,101,102

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