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Mutation and oxidative damage of mitochondrial DNA and defective turnover of mitochondria in human aging
Prx3 homodimer has a redox-sensitive cysteine that upon reaction with H 2 O 2 is oxidized to Cys-SOH, which then reacts with neighboring Cys-SH of the other subunit to form an intermolecular disulfide that can be readily reduced by thioredoxin reductase 2 (TrxRD2
Hospitals worldwide use pharmaceutical-grade NAC as a life-saving antidote, which proves its potency and safety profile
It is also generally advised against people having Wilson's disease or any other health issue affecting copper metabolism, because of the presence of copper-binding peptide in this formulation
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