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Glucagon-like peptide-1 excites firing and increases GABAergic miniature postsynaptic currents (mPSCs) in gonadotropin-releasing hormone (GnRH) neurons of the male mice via activation of nitric oxide (NO) and suppression of endocannabinoid signaling pathways
He now specializes in evidence-based weight management, including GLP-1/GIP therapies (semaglutide & tirzepatide)
High Stress and Poor Sleep Elevated cortisol promotes fat storage, especially in the abdominal region
It is not uncommon for patients using tirzepatide for weight loss to lose 10 to 15% or more of their starting body weight over a year of usage
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