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Despite the availability of FDA-approved anti-obesity medications (AOMs), they are rarely prescribed when indicated for a number of reasons
LRRK2 mutations (such as G2019S) promote mitochondrial fission in microglia by enhancing kinase activity, releasing mtROS and other factors to activate the NLRP3 inflammasome, exacerbating neuroinflammation in PD, and their regulation of mitochondrial dynamics has potential associations with ferroptosis (124)
This wide array of potential applications makes it a compelling subject for continued scientific inquiry
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