With an inconsistent one, each refill cycle becomes a question mark
Shi H, Zheng Y, Zhao J, Li Y, Jia H, Hou X, Li Y, Li J, Wu C, Gao L (2023) Zexie decoction reduce glucose-dependent lipid accumulation and oxidative stress in Caenorhabditis elegans
However, berberine is not approved as a pharmaceutical drug in most countries and lacks the decades of safety and efficacy data that metformin carries
As such, it appears that COVID-19 (and other viral infectious diseases) is accompanied by three different inflammatory phases: (a) beneficial protective inflammation, which combats the infection and may mount a restorative repair, (b) hyperinflammation, which may lead to a cytokine storm and critical disease or even death, and (c) non-resolving inflammation resulting in a protracted mild inflammatory state [105] as observed in Long COVID
10.1016/s0076-6879(85)13050-8 Methods Enzymol