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Subgroup analyses revealed important differences based on comparator drugs: GLP-1RAs demonstrated greater effectiveness than SGLT2 inhibitors in preventing MALOs (IRR: 0.93, 95%CI: 0.87-0.99, P = 0.043), than DPP-4 inhibitors in preventing hepatic decompensation events (IRR: 0.74, 95%CI: 0.66-0.83, P = 0.003), and than insulin therapy in averting HCC development (IRR: 0.32, 95%CI: 0.13-0.80, P = 0.033) [64]
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Pain 160(10):2365-2373, 2019
FDA accepted the label expansion for Zepbound (tirzepatide) for effectively including the four-dose single-patient use KwikPen that delivers a full month of treatment in one device
The goal is progressive overload, gradually increasing the challenge over time
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