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Treatment of mice with DS-induced colitis (resembling human ulcerative colitis) with the human GLP-2 analog h(Gly 2 )GLP, twice daily for 10 days, reverses weight loss independent on food intake, decreases interleukin-1 expression and increased colon length, crypt depth, and mucosal area compared to treatment with saline ( 2 )GLP-2 treatment also improves survival in drug-induced enteritis (non-steroidal anti-inflammatory drug - indomethacin) survival, reduces disease activity, decreases occurrence of intestinal ulcerations, and lowers cytokines and myeloperoxidase activity in mice ( Glp2r / mice, levels of various Paneth cell genes are lower in the jejunum and ileum, some specifically in charge of defensin activity suggesting alterations in gut barrier function
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