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Once IRS is phosphorylated, downstream signaling pathways are activated, including the phosphoinositide 3-kinase (PI3K) cascade and extracellular signal-regulated kinase (ERK)

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The dual roles of IL-1 in PD appear to reflect differences in signalling intensity and persistence, whereby chronic elevation is associated with neurodegenerative outcomes, whereas transient or low-level activation may be compatible with homeostatic or protective immune functions

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