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Separate common effects, urgent warning signs, and factors that raise risk
The 23andMe Research Institute paper published in Nature on April 8, 2026 (Su et al., n 28,000 GLP-1RA users) identified a missense variant in the GLP-1 receptor gene, rs10305420, associated with an additional -0.76 kg of weight loss per copy of the effect allele on GLP-1 monotherapy
Associations of classical HLA alleles with depression and anxiety
That distinction matters because weight loss should never be approached as a trend, shortcut, or one-size-fits-all protocol
Misoprostol reduces serious gastrointestinal complications in patients at risk for NSAID ulcers (MUCOSA trial)
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