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It states plainly that medications are tools rather than replacements for behavioral change, and describes GLP-1 therapy as working alongside lifestyle changes by enhancing satiety signaling and reducing hunger-driven eating
A 2026 analysis in the Journal of Medical Internet Research found real-world discontinuation rates far exceed clinical trial numbers, with up to 70% of patients stopping treatment within 24 months -- often because of these effects
At the lower doses used for diabetes, they have somewhat lower rates of diarrhea (9-12% for Ozempic, 12-21% for Mounjaro) compared to their weight management counterparts
Shed is the most comparable in simplicity
Br Med J (Clin Res Ed) 1985;290:811-815 Information & Authors Information Published In New England Journal of Medicine Pages: 1834-1844 Copyright Copyright 2016 Massachusetts Medical Society
