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MTX primarily acts by inhibiting dihydrofolate reductase (DHFR), which catalyzes the sequential conversion of folic acid to dihydrofolate (DHF) and tetrahydrofolate (THF)
Some patients prefer morning injections because they want to experience appetite suppression throughout the day, while others choose evening injections to manage nausea during sleep if it occurs
It restores it
doi: 10.1016/S0006-2952(02)01175-9 23
Cancer Cell 23 , 739752 (2013)
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