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118 In ER/HER2 breast cancer, hyperactivated AKT1 binds to the kinase domain of TBK1, disrupting the STING-TBK1-IRF3 complex, thereby impairing downstream interferon signaling and blocking innate immune responses triggered by DNA damage

In addition, ANGPTL4 promotes intracellular furin-mediated cleavage and inactivation of LPL

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