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This type of hyperammonemia can be treated with antibiotics to kill the bacteria that initially produce the ammonia, though this does not work as well as the removal of protein from the colon prior to its digestion to ammonia, achieved by lactulose administration for frequent (3-4 per day) bowel movements
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In an announcement of the study on the Vanderbilt website, lead author Khrysta Baig described this as a purely hypothetical scenario, but one that underscores that at current prices, these medications cannot be the only way or even the main way we address obesity as a society. In a more conservative estimate, Bhaig and coauthors consider a case where only about 10% of those eligible for obesity treatment opted for semaglutide, which would result in $27 billion in new costs
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