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2.4 Other metformin-related pathways In addition to ferroptosis, autophagy, and necrosis, metformin may influence other signaling pathways that lead to cell death such as apoptosis
ROS influence proteasomal, lysosomal, and mitochondrial function, which, in turn, regulate the cellular response to oxidative damage (Cook et al., 2012)
However, the trial has been terminated because the interim analysis showed that ODSH had no effect on the safety of patients with acute exacerbation of COPD 177 (Table 3)
Cell Death Dis 4 , e736 (2013)
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