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[4] The feedback loop model proposes: collagen degrades with age, releasing GHK fragments

Organoids were incubated in Cell Recovery solution (354253) for 30 min at 4 C

A similar scenario has in fact been reported recently in an alcoholic liver disease model in which long-term alcohol consumption activated NF-B in Kupffer cells, whereas NF-B activation in hepatocytes was inhibited 45

From this synthesis, we propose restoration of copper balance using copper delivery agents in combination with chaperones/chaperone mimetics, perhaps in conjunction with the neuroprotective amino acid serine, as a promising strategy in the treatment of this incurable disease