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It is known that the acute HPA response to stress plays an important role and has numerous functions which promote cells survival, but chronic activation of this axis by stressful episodes may lead to a wide range of pathological conditions, including depression

[15] He began heavily focusing on biohacking while taking part in the 2011 Hawaii Ironman Triathlon

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By keeping the structure so close to the native hormone, the researchers aimed to create a compound that would preferentially bind to the primary target, the MC1R, with minimal spillover to other receptors