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Initially intended for those with Type 2 diabetes because of their effectiveness in balancing blood sugar levels and their impact on insulin sensitivity, doctors quickly realized their off-label potential for weight loss, leading to their widespread popularity today

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In the Phase 2 trial, participants lost an average of 17.5% body weight by week 24 on the 12 mg dose

Some patients report dizziness, fatigue, or hypoglycemia if semaglutide is combined with other diabetes medications