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and stratified by CKD disease stage at index date (stage 3a or better, stage 3b, and stage 4 or worse)
Studies have shown that AMPK upregulates fatty acid oxidation genes (e.g., carnitine palmitoyl transferase 1 (CPT1) and peroxisome proliferator-activated receptor alpha (PPAR)) and downregulates synthesis genes (e.g., fatty acid synthase (FAS) and sterol regulatory element-binding protein 1c (SREBP-1c)) [67]
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doi: 10.1016/j.ijpddr.2017.07.001 16 FallatahO.GeorgesE
Obesity and Diabetes Drug Market Trends The U.S
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