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According to the American Diabetes Association (ADA), GLP-1 receptor agonists are now recommended as a first-line treatment in certain high-risk patients, especially those with established cardiovascular disease
In the STEP 1 trial extension phase, participants who discontinued semaglutide regained approximately two-thirds of their lost weight within one year
Water retention Temporary fluid retention during initial weeks, more common with the DAC formulation
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This is a practical choice that keeps injection volumes small while fitting within standard vial capacity
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