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Tacrolimus: In a pediatric patient with idiopathic nephrotic syndrome, clinically relevant increases in tacrolimus concentrations and renal toxicity occurred when berberine was added to control diarrhea (30)

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The effect of DSIP on GABA receptors and glutamate receptors in neurons of the hypothalamus, thalamus, cortex, hippocampus, and cerebellum has been at least partially attributed to motor function recovery in test subjects [15, 16, 17]